Characterization of the mouse bone marrow-derived stem cells for their use to treat autoimmunity and induce transplantation tolerance:

Hematopoietic stem cells are capable of both self-renewal and of giving rise to differentiated progenitor cells. Interactions of stromal cells (mesenchymal cells) and growth factors with hematopoietic stem and progenitor cells are responsible for production of mature cells. The goal is to establish an in vitro culture system that allows for activation and differentiation of a defined population of purified stem cells in response to soluble growth factors/cytokines or establishment of sromal layers from bone marrow. We will identify factors that regulate and promote stem/progenitor cell activation and differentiation to early progenitor cells, in addition to facilitating and enhancing their engraftments and differentiation following transplantation. The ultimate goal is to use bone marrow-derived stem/progenitor cell-based transplantation protocols to treat autoimmunity, to restore tissue vascularization, and to provide therapy for bone repair..

Key Investigator: Maryam Hairiri, Ph.D.